Alprazolam is primarily metabolized by CYP3A4 and commonly associated with more drug-drug interactions than lorazepam. Inhibitors of CYP3A4 like
Clindamycin is a substrate of CYP3A4 and to a lesser extent, CYP3A5. It is a moderate inhibitor of CYP3A4. Drugs that inhibit CYP3A5 or CYP3A4 may cause increased blood concentrations of clindamycin. CYP3A4 or 3A5 inducers may decrease plasma concentrations of clindamycin.
CYP3A4 INHIBITORS: Drugs that inhibit CYP3A4 activity generally decrease hepatic clearance and increase the plasma concentration of CYP3A4 substrate medications
Clindamycin is a substrate of CYP3A4 and to a lesser extent, CYP3A5. It is a moderate inhibitor of CYP3A4. Drugs that inhibit CYP3A5 or CYP3A4 may cause increased blood concentrations of clindamycin. CYP3A4 or 3A5 inducers may decrease plasma concentrations of clindamycin.
Studies have shown that drugs that induce CYP3A4 can decrease tadalafil exposure. CYP3A4 (e.g, Rifampin) Rifampin (600 mg daily), a CYP3A4 inducer, reduced
Clindamycin is a substrate of CYP3A4 and to a lesser extent, CYP3A5. It is a moderate inhibitor of CYP3A4. Drugs that inhibit CYP3A5 or CYP3A4 may cause increased blood concentrations of clindamycin. CYP3A4 or 3A5 inducers may decrease plasma concentrations of clindamycin.
Grapefruit juice is a CYP3A4 inhibitor. See DRUG INTERACTIONS, CYP3A4 INHIBITORS above. Drug-Laboratory Interactions. Corticosteroids may
Clindamycin is a substrate of CYP3A4 and to a lesser extent, CYP3A5. It is a moderate inhibitor of CYP3A4. Drugs that inhibit CYP3A5 or CYP3A4 may cause increased blood concentrations of clindamycin. CYP3A4 or 3A5 inducers may decrease plasma concentrations of clindamycin.
Drug interaction overview. CYP3A4 substrate (major); shows induction and time-dependent inhibition of CYP3A4. Strong CYP3A4 inhibitors. Decrease avacopan dose
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