Ibuprofen metabolized

Medical stuff:
Fracture = broken. We have lots of terms to describe the fracture, but a fracture is a break.
People can walk on a broken ankle if they are tough enough to take the pain and the tibia is not where the fracture is.
She would have had an x-ray about a week after the surgery to confirm it was well healing.
Plaster? We more often use water activated fiberglass these days. Less heat as it cures, sets quicker.
Very likely she would have been put in a walking boot.
Advil = Motrin = ibuprofen. Each pill is 200mg, so three were a good choice, four a bit better. Redose after six hours if the pain has returned.

Loved the story - but just as an aside, aspirin actually prevents liver damage. Acetameniphen (Tylenol) is what is traditionally known as dangerous for the liver, and non-aspirin NSAIDs such as ibuprofen have recently been linked to stroke/heart attack risk increase. lol I know this has nothing to do with erotica, and your story is fantastic - but if it were me writing this? (and I do write a ton - I'm actually a professional author), I would have had Jack (the athlete) share his prescription pain killers with his victim, since he's most likely on them (athletes are always getting hurt) and since opiate prescriptions, added Tylenol not withstanding, are the only things that don't increase the risk of liver damage and heart attack/stroke. Plus... let's be honest. They're also the only medications that actually work. And also - it's the very least Jack owes him. ;)

I like your story. Your caveat about discontinuities at the top was way too understated, they were jarring, but I get it. I've been there myself, but please remember to come back and clean up later, you're going to throw a lot of people off.
OK, big problem: Never, ever, ever take Advil and Tylenol together! Ever! Tylenol is Acetaminophen, it's a blood thinner. Advil is Ibuprofen, it's an anti-inflammatory that will also irritate your stomach lining. So between the two, you'll end up with a bleeding ulcer. I think the standard recommendation is to separate them by at least twelve hours, though I just stick to one. So unless you're TRYING to mess Hayley up even worse than she already is (bruised, battered, hung over), PLEASE stick to one or the other.
PS: Yes, this is a pet peeve. Yes, I've personally had a problem with both drugs. Google it if you don't believe me.

When you refer to lifelong I think some more explanation is due. Did you lack the sexual cravings that almost all adolescents have? Did you masturbate before having sexual contact with another person? Not intercourse per se, but kissing, fondling..etc? Have you ever experienced an orgasm, with or without a partner? Does your vagina lubricate when you are exposed to sexual situations? As far as males with low libidos, often that's a result of another underlying physical, or mental anomaly. Please don't scare people, exogenous testosterone creams carry little risk. Most that find themselves in need of these creams are not under forty years of age, and usually older than than that. While I wouldn't recommend them to anyone who has had prostate cancer the risk is minimal. Taking over the counter medications such as Advil, Motrin, which are both ibuprofen, can cause severe kidney damage in large amounts, yet are safe minus pre-existing kidney problems, when taken properly they provide effective and safe relief from pain. The same can be said for exogenous or injected testosterone and estrogen provided it is used correctly. HSDS can, and does come with life changing effects. It has the ability to prevent and kill marriages. So if pharmocological therapy can eliminate or reduce the aforementioned effects, it should be understood that it remains a viable and safe option in the treatment HSDS.

The premise is fun and I really love stories where it's the unintended or unforeseen consequences that get someone's goat. Having said that, I thought the prologue was jumped too far, too fast. Things were going okay until the medical testing.... and then jumping right into giving the employees some kind of bonuses and signing a whole new contract? That came out of nowhere and we have no real explanation for it. The company is well-established and has been in place for years, so why this talk about new contracts, morality clauses, etc? They can't be planning on the drug being a success since.... it's not even made it to clinical trials. That she took a couple pills and nothing happened is no way indicative of the pills being good for all humans -- something scientists would know. We literally jump from one scene to the next and have no idea who the characters are, how they really relate to each other, how they feel about their coworkers, etc.
Being the start of the story, I would suggest that more time be taken in actually developing the characters. Also, if you're going to have a characters be all scientific, you really should study up more on the scientific method.
Nobody who is the least bit medically or scientifically trained would take a handful of experimental pills like that. Take one and monitor. A few days later after that one pill has metabolized out of the system and no ill effects can be found, you might try 2 pills and repeat the observation process. You'd continue doing that until you reached a fair conclusion regarding unwanted side-effects, but you still don't know if ingesting those pills is causing long-term damage like cancer, ulcers, etc.
Granted, this is a fun story and not meant to be hidebound to the Scientific Method. Little things, though, really make it hard to take seriously because it so thoroughly shatters the suspension of disbelief. No science prodigy or Nurse PhD would ever in a million years suggest downing a dozen pills in the same day she downed five pills. It would never happen. They have no idea what the physical reaction to that large a dose might be even though there was no serious reaction to a smaller dose.
On top of that, drinking alcohol is a known no-no that any science prodigy would understand could actually kill her now that she has a bellyful of experimental drugs. No Nurse PhD would allow her to drink, but this also brings us back to the problem of them celebrating in the first place. Why are they celebrating? The first half of the story clearly states that they are still a long way off from getting the approval of the FDA, so what's there to party over? Their one test was only the least bit good news in that it gave them a minuscule measure of hope that there wouldn't be any negative side effects for humans -- but that was one test on one person over just one day. They still have a long way to go before their pill can be marketed. So what's to celebrate?
Please don't take this as a dig on your work. The premise is solid, but the details need to be fleshed out. I'll look forward to reading the next chapter.