Mao drugs

MECHANISM OF DRUG INTERACTION. MAO exists as 2 isoforms, MAO-A and MAO-B. Inhibition of MAO-A reduces the metabolism of both serotonin and noradrenaline, whereas inhibition of MAO-B does not affect the metabolism of these neurotransmitters, unless sufficient doses (as described below) are used. 15 Inhibition of MAO-B, the major isoform in the

Examples of Drugs 1.Non-selective MAO inhibitors Inhibit both MAO-A. Examples of Drugs 2.Selective MAO-A Inhibitor Clorgiline (Clorgyline) .

Monoamine oxidase inhibitors are a class of antidepressant drugs that are Inhibitors of MAO-A and MAO-B in psychiatry and neurology.

The efficacy of the inhibitor binding into the unique substrate binding sites of MAO-A and MAO-B ultimately determines a drug s relative selectivity at inhibiting MAO-A, MAO-B, or both. The substrate binding sites of both MAO-A and MAO-B are mainly hydrophobic except for a conserved lysine that interacts with a water molecule.

Newer MAO inhibitor drugs, including selegiline (Eldepryl) and rasagiline (Azilect), target MAO-B and are called selective MAO inhibitors. Selegiline is

Examples of Drugs 1.Non-selective MAO inhibitors Inhibit both MAO-A. Examples of Drugs 2.Selective MAO-A Inhibitor Clorgiline (Clorgyline) .

MAO is a flavin-containing enzyme critical for regulating MAO inhibitors and other serotonergic drugs is associated with the

The monoamine oxidase (MAO) enzymes include MAO-A and MAO-B. The catecholamines are metabolized by both MAO-A and MAO-B, whereas 5-HT is metabolized only by MAO-A. The four irreversible MAOIs marketed in the United States include the nonselective MAOIs phenelzine and tranylcypromine and the MAO-B selective drugs selegiline and isocarboxazid ((2)).

by Z CAI 2024 Cited by 226As MAO is well known for its effects on neurotransmitter substance and MAO inhibitors MAO-B inhibitor antiparkinsonian drug, rasagiline. Drugs