Hepatic insufficiency: − Omeprazole: In − Methotrexate - PPIs possibly reduce excretion of methotrexate, leading to an increased risk.
Both Methotrexate and Olaparib can increase the risk of myelosuppression. Omeprazole. Omeprazole decreases the clearance of Methotrexate (high-dose).
The serum concentration of Methotrexate can be increased when it is combined with Omeprazole. Metabolizes methotrexate (MTX) to polyglutamates.
Omeprazole taken with clopidogrel can lower the activity of clopidogrel, so avoid taking these drugs together. Taking omeprazole with methotrexate may result in high levels of methotrexate or methotrexate toxicity. Your doctor may temporarily stop omeprazole treatment if you are taking a high dose of methotrexate.
Omeprazole and Methotrexate. Omeprazole can increase the blood levels and side effects of methotrexate. Concomitant use of the two drugs may elevate and prolong serum concentrations of methotrexate and its metabolite hydroxymethotrexate, possibly leading to methotrexate toxicities. Omeprazole and Clopidogrel (Plavix)
Methotrexate, The serum concentration of Methotrexate can be increased when it is combined with Omeprazole. Methsuximide, The metabolism of Methsuximide can
omeprazole, esomeprazole, and pantoprazole may decrease methotrexate clearance, leading to elevated serum levels of methotrexate and/or its
There is evidence that co-administration of methotrexate and omeprazole prolongs the elimination of methotrexate via kidneys. Co-administration of proton
Omeprazole and Methotrexate. Omeprazole can increase the blood levels and side effects of methotrexate. Concomitant use of the two drugs may elevate and prolong serum concentrations of methotrexate and its metabolite hydroxymethotrexate, possibly leading to methotrexate toxicities. Omeprazole and Clopidogrel (Plavix)
Hence Omeprazole being a much more expensive drug than it is now.....