Hemophagocytic Lymphohistiocytosis (HLH): Cases of HLH have been reported in pediatric and adult patients treated with Zosyn. dose of Zosyn should be reduced
2.1 Important Administration Instructions. If a dose of ZOSYN is required that does not equal 2.25 g, 3.375 g, or 4.5 g, ZOSYN injection in GALAXY Containers is
Zosyn (preferred for enterococcus coverage) OR cefepime/Flagyl (if unable to use Zosyn). Requires renal dose adjustment. This chart is for empiric coverage
Pharmacists will assess, interchange and renally adjust standard doses of Zosyn with extended- infusions as described in the adult dosing chart below.
Dosage for Zosyn Injection. The usual total daily dose of Zosyn for adults is 3.375 g every six hours totaling 13.5 g (12.0 g piperacillin/1.5 g tazobactam).
For pyelonephritis and complicated cystitis: The usual dose of ZOSYN for I.V. infusion bag for adults is a single 4.5 g dose of tazobactam and
Adjust dosing frequency in renal insufficiency: receiving Zosyn. This would be consistent with the potential ADR of lowering
Zosyn, Zosyn Injection; Drug Class: Penicillins, Extended-Spectrum doses given IV in the presence of renal impairment; Consider sodium content
Drug interactions of Zosyn include probenecid, which may inhibit the renal In one study, 222 patients were treated with Zosyn in a dosing regimen of
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