Hydroxybupropion

Radafaxine ; (S,S)-Hydroxybupropion; (2S,3S)-Hydroxybupropion; GW-353,162 Oral none.

erythrohydrobupropion, threohydrobupropion, hydroxybupropion 800 mg, the pharmacokinetics of bupropion and hydroxybupropion were unaffected.

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Hydroxybupropion (code name BW 306U), or 6-hydroxybupropion, is the major active metabolite of the antidepressant and smoking cessation drug bupropion.

Genetic variation in CYP2B6, the enzyme that metabolizes bupropion to hydroxybupropion, was identified as a significant source of variability in hydroxybupropion formation. Our data indicate that hydroxybupropion contributes to the pharmacologic effects of bupropion for smoking cessation, and that variability in response to bupropion treatment

Hydroxybupropion (code name BW 306U), or 6-hydroxybupropion, is the major active metabolite of the antidepressant and smoking cessation drug bupropion.

The aminoketone structure of bupropion is metabolized in the liver by the cytochrome P450 isoenzyme CYP2B6 to the active metabolites R,R-hydroxybupropion, S,S-hydroxybupropion, threohydrobupropion, and erythrohydrobupropion, which are responsible for the pharmacological activity of bupropion .

Metabolites. 4-hydroxybupropion is a metabolite of the following: bupropion. (source: PharmGKB)

Hydroxybupropion (code name BW 306U), or 6-hydroxybupropion, is the major active metabolite of the antidepressant and smoking cessation drug bupropion.