Reactions to ibuprofen

Overview: Ibuprofen/famotidine is a combination medicine that is used to treat osteoarthritis and rheumatoid arthritis and lower your risk of getting stomach ulcers. Ibuprofen works to block certain substances in the body that cause pain, inflammation, and fever while famotidine works to lower the amount of stomach acid in your body. Common side effects include nausea, diarrhea, constipation, stomach pain, and headache. Before taking ibuprofen/famotidine, make sure to tell your healthcare provider about any health conditions or medications you are taking.What is ibuprofen/famotidine used for?Ibuprofen/famotidine is a combination medicine. Ibuprofen is commonly used to treat pain and swelling caused by osteoarthritis and rheumatoid arthritis. Famotidine lowers the risk of developing stomach ulcers while on ibuprofen. Ibuprofen/famotidine may also be used for other conditions as determined by your healthcare provider.How does ibuprofen/famotidine work (mechanism of action)?Ibuprofen works by blocking certain substances in the body that cause pain, inflammation, and fever. Famotidine works to lower the amount of acid that your stomach releases. How is ibuprofen/famotidine supplied (dosage forms)?Brands and other namesDuexisDosage forms and strengths800 mg/26.6 mg oral tabletsHow should I store ibuprofen/famotidine?Ibuprofen/famotidine should be stored at room temperature, between 68 F to 77 F (20 C to 25 C). It can be exposed to temperatures between 59 F to 86 F (15 C to 30 C) for shorter periods of time, such as when transporting it. Store in a cool, dry place. Side Effects What are the most common side effects of ibuprofen/famotidine?The most common side effects of ibuprofen/famotidine are listed below. Tell your healthcare provider if you have any of these side effects that bother you.NauseaDiarrheaConstipationStomach painHeadacheThere may be other side effects of ibuprofen/famotidine that are not listed here. Contact your healthcare provider if you think you are having a side effect of a medicine. In the U.S., you can report side effects to the FDA at www.fda.gov/medwatch or by calling 800-FDA-1088. In Canada, you can report side effects to Health Canada at www.health.gc.ca/medeffect or by calling 866-234-2345.What are the serious side effects of ibuprofen/famotidine?While less common, the most serious side effects of ibuprofen/famotidine are described below, along with what to do if they happen.Severe Allergic Reactions. Ibuprofen/famotidine can cause allergic reactions, including a specific type of allergic reaction called DRESS. DRESS stands for Drug Reaction with Eosinophilia and Systemic Symptoms. It is also sometimes called multiorgan hypersensitivity. This is a reaction that can affect multiple parts of the body,

Urine. The excretion of ibuprofen is virtually complete 24 hours after the last dose. The serum half-life is 1.8 to 2.0 hours. Studies have shown that following ingestion of the drug, 45% to 79% of the dose was recovered in the urine within 24 hours as metabolite A (25%), (+)-2-[ p-(2hydroxymethyl-propyl) phenyl] propionic acid and metabolite B (37%), (+)-2-[ p-(2carboxypropyl)phenyl] propionic acid; the percentages of free and conjugated ibuprofen were approximately 1% and 14%, respectively. Indications And Usage Carefully consider the potential benefits and risks of ibuprofen tablets and other treatment options before deciding to use ibuprofen. Use the lowest effective dose for the shortest duration consistent with individual patient treatment goals (see WARNINGS ). Ibuprofen tablets are indicated for relief of the signs and symptoms of rheumatoid arthritis and osteoarthritis. Ibuprofen tablets are indicated for relief of mild to moderate pain. Ibuprofen tablets are also indicated for the treatment of primary dysmenorrhea. Controlled clinical trials to establish the safety and effectiveness of ibuprofen tablets in children have not been conducted. Contraindications Ibuprofen tablets are contraindicated in patients with known hypersensitivity to ibuprofen. Ibuprofen tablets should not be given to patients who have experienced asthma, urticarial, or allergic-type reactions after taking aspirin or other NSAIDs. Severe, rarely fatal, anaphylactic-like reactions to NSAIDs have been reported in such patients (see WARNINGS, Anaphylactoid Reactions and PRECAUTIONS, Preexisting Asthma ). Ibuprofen tablets are contraindicated in the setting of coronary artery bypass graft (CABG) surgery (see WARNINGS ). Warnings Cardiovascular Effects Cardiovascular Thrombotic Events

Having a medical emergency, you should call 911 or your local emergency number.Serious side effects of ibuprofen that have been reported include:anemia (low level of red blood cells)aseptic meningitis (swelling of the brain and spinal cord lining)kidney damage, especially when used long termliver problems, including hepatitis and liver failurevision problems, including:blurry visiondiminished visionchanges in color visionlife-threatening skin reactions, including:Stevens-Johnson syndrome (SJS)toxic epidermal necrolysis (TEN)boxed warnings:*risk of gastrointestinal (digestive) problems, including bleeding, ulcers, and perforation (tears) in the stomach and intestinesrisk of problems related to cardiovascular (heart and blood vessel) blood clots, including heart attack and strokesevere allergic reaction,† including drug rash with eosinophilia and systemic symptoms (DRESS)* For more information, see the “What should be considered before taking ibuprofen?” section.† To learn more about allergic reaction and ibuprofen, see the “Allergic reaction” section below.Allergic reactionSome people may have an allergic reaction to ibuprofen, although reports are rare.Symptoms of a mild allergic reaction can include:skin rashitchinessflushing (temporary warmth, redness, or deepening of skin color)A more severe allergic reaction is rare but possible. Symptoms of a severe allergic reaction can include swelling under your skin, usually in your eyelids, lips, hands, or feet. They can also include swelling of your tongue, mouth, or throat, which can cause trouble breathing.Call your doctor right away if you have an allergic reaction to ibuprofen. But if you think you’re having a medical emergency, call 911 or your local emergency number.Ibuprofen and acetaminophen (Tylenol) are both used for treating mild to moderate pain. But they work

Call your healthcare provider if your blood pressure increases while taking this medicine.If you measure your blood pressure and the top number (systolic) is 180 mm Hg or higher or the bottom number (diastolic) is 120 mm Hg or higher, get medical attention right away. An increase in blood pressure may not be noticeable but look out for any of the following symptoms of severely high blood pressure.Sudden severe headacheChest painDizziness or confusionTrouble breathingNausea/vomitingBlurry or other changes to visionAnxietyBuzzing in the earsNosebleedFeeling of skipped heart beatsHeart Failure. Ibuprofen may increase your risk for heart failure. Stop taking ibuprofen and call your healthcare provider right away if you have any of the following symptoms of heart failure.Shortness of breath or trouble breathing, especially while lying downSwelling in your feet, ankles, or legsUnusually fast weight gainUnusual tirednessKidney Damage. Kidney damage can happen when using Ibuprofen. Stop taking ibuprofen and call your healthcare provider right away if you have any of the following symptoms of kidney damage.Reduced need to peeSwelling in your feet, ankles, or legs (edema)Weakness or unusual tirednessDifficulty catching your breath or chest pain/pressureConfusionNauseaSeizuresSevere Allergic Reactions. Ibuprofen can cause allergic reactions, including a specific type of allergic reaction called DRESS. DRESS stands for Drug Reaction with Eosinophilia and Systemic Symptoms. It is also sometimes called multiorgan hypersensitivity. This is a reaction that can affect multiple parts of the body, including your liver, kidneys, and heart. Stop taking the medicine and get help right away if you have any of the following symptoms of a serious allergic reaction.Breathing problems or wheezingRacing heartFever or general ill feelingSwollen lymph nodesSwelling of the face, lips, mouth, tongue, or throatTrouble swallowing or throat tightnessItching, skin rash, or pale red bumps on the skin called hivesNausea or vomitingDizziness, feeling lightheaded, or faintingStomach crampsJoint painDark colored urineYour skin or the whites of your eyes turning yellowish in color (also called jaundice)Severe Skin Reactions. Ibuprofen can cause severe skin reactions called exfoliative dermatitis, Stevens-Johnson Syndrome (SJS) and Toxic Epidermal Necrolysis (TEN) that can lead to death if not treated. If you develop a rash, stop ibuprofen and call your